Nobilis® CAV P4

This is a live attenuated freeze-dried vaccine containing chicken anaemia vaccine virus.
Nobilis® CAV P4 is intended for the immunisation of healthy future breeding chickens against chicken anaemia.

FOR ANIMAL USE ONLY

Reg. No. G2467 (Act 36/1947)

Namibia Reg. No. V98/24.3/673 [NS0]

INDICATIONS

Nobilis® CAV P4 is intended for the immunisation of healthy future breeding chickens against chicken anaemia.

COMPOSITION

Nobilis® CAV P4 is a live attenuated freeze-dried vaccine containing chicken anaemia vaccine virus.

Each 1 mℓ dose contains at least 3,0 log10 TCID50 of chicken anaemia vaccine virus propagated on embryonated eggs. The freeze-dried pellet contains stabilisers.

IMMUNITY

The induction of high neutralising antibody levels is generally dependent on the health and condition of the chickens. Hygiene and management are also important in the post-vaccination period. Breeding chickens must be vaccinated at least 6 weeks before the onset of lay.

STORAGE INSTRUCTIONS

  • Store between 2 °C and 8 °C in a refrigerator.
  • Do not freeze.
  • Avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use.
  • Protect from direct sunlight.
  • The diluent may be stored at room temperature (20 °C to 25 °C) prior to use.

WARNINGS

  • Withdrawal period: Do not slaughter chickens for human consumption within 21 days after vaccination.
  • The vaccine must not be administered to chickens under 6 weeks of age.
  • Breeding chickens have to be vaccinated at least 6 weeks before the onset of lay.
  • Vaccinate healthy chickens only.
  • Do not inject intravenously.
  • Do not over- or under-dose the vaccine.
  • It is advisable to vaccinate all the susceptible chickens on the farm at the same time. If this is not feasible, strict separation of vaccinated and unvaccinated chickens should be done to prevent the spread of the vaccine virus to the unvaccinated chickens.
  • Do not open and reconstitute the vaccine until ready to start vaccination.
  • Use the vaccine immediately after reconstitution.
  • Use according to the number of doses as indicated on the label.
  • In case of accidental self-injection, seek medical advice immediately and show this package insert to the physician.
  • KEEP OUT OF REACH OF CHILDREN, UNINFORMED PERSONS AND ANIMALS.
  • Although this vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

PRECAUTIONS

  • Observe aseptic precautions. Ensure that all vaccination equipment (containers, syringes and needles) is clean and sterile prior to and during use. Use sterile equipment when administering the vaccine.
  • Do not use disinfectants or antiseptics to sterilise any equipment.
  • It is good vaccination practice to avoid contact with the eyes, hands and clothing when handling the vaccine. Wash hands after vaccinating.
  • Do not eat, drink or smoke whilst handling the product.
  • Adhere to the vaccination programme to obtain optimum results.
  • Destroy any unused vaccine and dispose of all the empty vaccine containers and disposable equipment after use in accordance with National Environmental Management: Waste Act, 2008 (Act No. 59 of 2008).
  • Do not contaminate rivers dams or any water sources with containers or waste.

DIRECTIONS FOR USE – USE ONLY AS DIRECTED

Intramuscular and Subcutaneous Injection

  1. Reconstitute the vaccine with Intervet’s diluent, Dilavia.
  2. Add some of the diluent to the vaccine vial, using a sterile syringe and needle, and shake.
  3. Withdraw the rehydrated vaccine into the syringe and add back to the rest of the diluent in the diluent bottle.
  4. Gently shake to mix.
  5. Withdraw a portion of the diluent to flush the vial and inject the fluid back into the diluent bottle.
  6. Remove the syringe.
  7. Fill the automatic syringe according to the manufacturer’s recommendation and set the dose to 0,2 mℓ.

Dosage

Every 0,2 mℓ contains 1 chicken dose (The amount of diluent to be used depends on the number of doses per vial). Administer the vaccine by the intramuscular or subcutaneous route.

Application by the Wing-web method

  1. Reconstitute the vaccine with the diluent as prescribed. For more information, contact your MSD Animal Health representative.
  2. After reconstitution of the vaccine with the diluent, the wing-web needle is dipped into the vaccine solution, before the vaccination of each chicken, so that both grooves are filled.
  3. The needle is inserted through the wing-web from beneath, taking care to avoid the feathered parts of the web.
  4. After 7 to 10 days of vaccination, the reaction should be examined in a certain number of chickens.
  5. The vaccination site should show minor swelling and small scabs which will disappear within 2 to 3 weeks.

VACCINATION PROGRAMME

The optimum time and method of administration depend largely upon the local situation. Therefore, the advice of a veterinarian should be sought. Under no circumstances should the vaccine be administered under 6 weeks of age. To make sure that adequate antibody levels are built up at the onset of lay, breeding chickens have to be vaccinated at least 6 weeks before this onset.

Vaccination against CAV can be combined with vaccination against Reo (intramuscular or subcutaneous route) or with vaccination against Chicken Pox (wing-web route)

PRESENTATION

Carton boxes containing 10 vials of 1 000 doses each, presented as a freeze-dried pellet.

REGISTRATION HOLDER                                      

Intervet South Africa (Pty) Ltd.                           

20 Spartan Road

Spartan, 1619, RSA                                                    

Tel: +27 (0) 11 923 9300                                          

E-mail: msdahza@msd.com

www.msd-animal-health.co.za

DATE OF PUBLICATION OF THIS PACKAGE INSERT

26 February 1998